Know the composition of air (in mole fractions and partial pressures).
Be able to explain the difference between the concentration and partial pressure of a gas dissolved in a liquid.
Know the partial pressure of water and 37 deg. C and its significance to respiration.
Modified 5/14/06 - Be able to sketch the general shape and describe the interesting features of the oxygen-blood dissociation curve.
Be able to describe the Bohr Shift and its mechanism.
Modified 5/14/06 - Be able to sketch the general shape and describe the interesting features of the carbon dioxide-blood dissociation curve.
Be able to describe the Haldane Effect and its mechanism.
Be able to explain the interactions between O2 and CO2 exchange in the blood (see handouts).
Know how the ratio of ventilation to perfusion effects alveolar gas composition and the effectiveness of the lungs.
Know how to use the Henderson-Hasselbalch equation to calculate the effect of PCO2 and [HCO3-] on blood pH.
Be able to explain the mechanism by which the PCO2 effects blood pH.
Added 5/14/06 - Be able to sketch and label the pH-Bicarbonate diagram including blood buffer lines and carbon dioxide isobars.
Be able to explain the significance of the blood buffer lines (lines of constant base excess) on the pH-Bicarbonate diagram.
Be able to explain the significance of the carbon dioxide isobars (lines of constant PCO2) on the pH-Bicarbonate diagram.
Know the various forms in which carbon dioxide is carried in the blood.
Be able to identify and distinguish among compensated and uncompensated respiratory and metabolic acidosis and alkalosis.